Purinergic Receptors: Key Mediators of HIV-1 infection and inflammation

Purinergic Receptors: Key Mediators of HIV-1 infection and inflammation

Blog Article

Human immunodeficiency virus (HIV-1) causes a chronic infection that afflicts more than 38 million individuals worldwide.While the infection can be suppressed with potent anti-retroviral therapies, individuals infected with HIV have Cholesterol Synthesis elevated levels of inflammation as indicated by increased T cell activation, soluble biomarkers, and associated morbidity and mortality.A single mechanism linking HIV pathogenesis to this inflammation has yet to be identified.Purinergic receptors massagers-small are known to mediate inflammation and have been shown to be required for HIV-1 infection at the level of HIV-1 membrane fusion.Here we review the literature on the role of purinergic receptors in HIV-1 infection and associated inflammation and describe a role for these receptors as potential therapeutic targets.